Diabetes mellitus may cause generalized pain, such as diabetes mellitus with long duration plus poor blood sugar control can cause peripheral neuropathy, which can lead to generalized pain, numbness, hyperalgesia, etc. When diabetes mellitus patients are combined with rheumatism, osteoporosis, muscular atrophy and other complications, generalized pain and discomfort may also occur. Diabetic patients are mostly middle-aged and old people, clinically, the main manifestations of periapical pain, weakness of both lower limbs, generalized muscle aches and pains, and other symptoms. The most common cause is diabetic neuropathy, causing generalized neuropathic pain. In terms of treatment, some drugs that treat nerves and nourish nerves are mostly used, such as pregabalin, gabapentin, duloxetine and so on. In addition, it may be caused by rheumatic, rheumatoid and other diseases combined with diabetes and thus cause generalized pain, at this time, it is necessary to target the original disease treatment, such as non-steroidal anti-inflammatory drugs ibuprofen, celecoxib and so on. The above drugs should be used under the guidance of a doctor, diabetic patients with generalized pain is recommended to the hospital for further examination, do not use drugs.