The plantar warts are caused by human papillomavirus infection, the number of skin lesions damage is variable, often only 1~2, or a lot of and scattered in all parts of the foot, or a dense distribution. The group metatarsal warts can be treated by topical salicylic acid ointment, 5% fluorouracil ointment, 5% imiquimod ointment, or local injection of paxillin, bleomycin and other drugs. The use of drugs should be under the guidance of medical professionals. Liquid nitrogen cryotherapy, laser, electrocoagulation and other physical treatments can also be used to remove grouped plantar warts, and good skin care is needed to keep the wounds hygienically clean and dry after surgery.