This disease was first reported by Wells in 1971 under the name of recurrent granulomatous dermatitis with eosinophilia. The disease is a syndrome with characteristic clinical resemblance to acute cellulitis lesions, significant eosinophil infiltration on biopsy, tissue edema, and flame phenomenon. The disease is characterized by recurrent pruritic cellulitis-like edematous erythematous or pemphigoid lesions on the extremities and trunk. Initial lesions are seen on the extremities or trunk, single or multiple, as small erythematous patches, soon followed by large red plaques, edema, infiltrates or urticaria-like lesions with clear boundaries and itching or slight pain. Within 2-3 days, it rapidly extends to the entire limb, occasionally with blisters and macules, etc. In severe cases, painful acute bacterial cellulitis-like damage occurs in the skin, but it does not respond to antibiotic treatment. Late stage manifests as infiltrative granuloma-like masses or nodules within the dermis or subcutaneously, with fading erythema and some plaques with greenish changes before fading. The center may recede with a rose-red or purple margin, and there may be ring-like plaques. Sometimes resembles the appearance of scleroderma. It usually lasts for 3-6 weeks before the masses subside or leave hard nodules and skin atrophy, often without scarring. Post-inflammatory hyperpigmentation is present. The disease may resolve spontaneously, but often recurs. The duration of the disease can last from several weeks to several years.