Vomiting and heartburn in diabetic patients undergoing dialysis may be due to metabolic toxicity, dialysis imbalance syndrome, etc. The presence of high blood pressure may be caused by the use of high-calcium dialysis solution or dehydration. Patients can improve their symptoms through medication, improved dialysis methods, and fluid replacement. 1. Vomiting and heartburn: Due to the abnormal metabolic function of kidneys, metabolic acidosis occurs when carbon dioxide binding capacity is significantly lower than normal after hemodialysis treatment. It can cause nausea, vomiting, heartburn sensation and other symptoms. Sodium bicarbonate solution can be used to neutralize the acidity and relieve the symptoms. It may also be a dialysis imbalance syndrome caused by excessive removal of toxins from the body, among other things. Patients may experience symptoms such as increased cranial pressure leading to nausea, vomiting, and a feeling of heartburn. Patients can slow down the speed of dialysis, especially for patients who have just entered the dialysis treatment, it is advisable to use a gradual method, gradually extend the dialysis time, and use low flux, small membrane area dialyzer. 2. High blood pressure: the use of high calcium dialysis solution may increase the vascular tension and myocardial contractility, which may lead to the increase of blood pressure. Patients can be treated with medications, such as enalapril and irbesartan, which can improve the symptoms of high blood pressure. Dehydration leads to an increase in some kind of vasoconstrictor substances in the blood, such as sympathetic nerve excitation, renin angiotensin activation, leading to vasoconstriction caused by the phenomenon of high blood pressure. The patient is advised to rehydrate promptly. Patients are advised to go to the hospital and follow the doctor’s instructions for treatment to avoid delay.