At present, the oral treatment drugs for premature ejaculation mainly include 5-hydroxytryptamine reuptake inhibitors and tricyclic antidepressants, but the specific efficacy varies from person to person, and the drugs should be used in accordance with the doctor’s prescription. 1.5-hydroxytryptamine reuptake inhibitors: such as dapoxetine, paroxetine, fluoxetine, etc., of which dapoxetine is the basic and preferred drug in the comprehensive treatment of premature ejaculation. These drugs are prohibited to be used in combination with pimozide, methylthiopyridazine and monoamine oxidase inhibitors such as linezolid, phenelzine, etc. Adverse effects include dizziness and nausea. 2. Tricyclic antidepressants: such as chlorpromazine is the first antidepressant used in the treatment of premature ejaculation, but the current clinical application is still small, need to be used with caution. This kind of drug is prohibited for those who are allergic to it or have serious heart disease, glaucoma and other conditions, adverse reactions include dry mouth, constipation and so on. However, it should be noted that the specific efficacy of the use of the above drugs may vary depending on the physical condition of the user and compliance, the severity of premature ejaculation, and other factors, and in addition to oral medication, topical local anesthetics (e.g., Lidocaine, proparacaine, etc.) are also commonly used in the treatment of premature ejaculation, and there are also clinical options such as psychotherapy and surgical treatments. Therefore, people diagnosed with premature ejaculation must be under the guidance of a doctor, according to the actual situation of the individual choice of drugs and other treatment methods, do not dispose of their own, blindly use drugs, in order to avoid improper intervention, resulting in adverse consequences.