There is no fastest way to eliminate the blisters in the mouth, the blisters in the mouth is considered to be related to traumatic blisters, oral herpes simplex, oral ulcers, etc., you can follow the doctor’s instructions to use medication. 1. traumatic blisters: if the volume of small blisters, usually without special treatment, to be absorbed on its own. If the blisters are large, they can be treated by using a sterile syringe to aspirate the fluid inside the blisters. 2. Oral herpes simplex: patients can follow the doctor’s instructions with 3% acyclovir ointment, 1% penciclovir cream and other medications, but also systemic application of acyclovir, vasiclovir and other antiviral drugs. For recurrent herpes labialis, low energy laser treatment is feasible. 3. Oral ulcers: in the attack period, pain patients can be applied locally lidocaine gel, benzocaine gel and other pain medication, but also available recombinant human epidermal growth factor, recombinant bovine basic fibroblast growth factor gel and other drugs to promote healing. Anti-inflammatory drugs such as chlorhexidine gargle or cediriodine tablets can be used on a daily basis, and laser irradiation can also be used in some patients. It is recommended that people with blisters in their mouths should consult a doctor for examination, and follow the doctor’s instructions for treatment after clarifying the disease, and should not use drugs indiscriminately. The daily attention to diet rationality, avoid intake of spicy stimulating food, so as not to aggravate the state of the skin lesions. Drugs should be used under the guidance of a physician.