Blood uric acid 443μmol / L may be increased uric acid production or decreased excretion, such as excessive intake of purines, the use of drugs to inhibit uric acid excretion, certain kidney diseases, etc., you can temporarily do not eat uric acid-lowering drugs, if through the general treatment is still no decline or complications of joint symptoms, you need to take uric acid-lowering drug therapy. Daily diet, non-same day twice fasting blood uric acid 420μmol / L is called hyperuricemia, some can be no clinical symptoms, with age, may appear gouty arthritis and other symptoms, elevated uric acid may be due to excessive intake of purines, the use of drugs to inhibit the excretion of uric acid, or certain kidney disease. When the uric acid is 443μmol/L, you can first improve the diet structure, such as limiting alcohol, controlling the total calorie intake per day, reducing the consumption of high-purine diet, such as animal offal, seafood, etc., and drinking more water, more than 2000ml per day, in order to promote uric acid excretion, avoiding the use of diuretics such as furosemide, hydrochlorothiazide, etc., which inhibit the excretion of uric acid. When the blood uric acid is still higher than 420umol/L after the above ways or complicated with joint symptoms, oral medication is needed, such as benzbromarone, allopurinol, febuxostat, etc. to reduce uric acid, diclofenac sodium, etc. to relieve pain, and if there is renal disease, it is necessary to promptly target the primary pathology for treatment. If the blood uric acid is found to be 443μmol/L, it is recommended to go to the hospital in time and standardize the treatment under the guidance of the doctor.