Dry corneal spots are the result of a deficiency of vitamin A. So how should the disease be examined? 1, eye symptoms The earliest symptoms are unclear vision in a dark environment, orientation difficulties, and night blindness, which is easy to ignore if not carefully examined. After several weeks to months, the conjunctiva and cornea gradually lose their luster and become abnormally dry when slightly exposed to air. Especially the conjunctiva close to the cornea on both sides of the earliest changes, dry and wrinkled, keratinous epithelium gradually regulation, the formation of varying sizes of white spots shaped like foam, known as conjunctival dry spots, also known as Bitt’s spot. At this time, the epithelial cells of the lacrimal gland degenerate, tear secretion is reduced, plus the lacrimal duct is blocked by the shed epithelial cells, tears are even less. The affected child is photophobic, feels dry and uncomfortable, has pain in the eye, has a gritty feeling, blinks frequently, or rubs the eye with his hand, which can easily lead to secondary infection. The cornea becomes progressively dry, cloudy, and softened with white opacity. As the disease progresses, the cornea may become ulcerated, and within a few days to a few weeks, necrosis, perforation, iris exfoliation and corneal scar formation may occur, leading to blindness, as well as retinal lesions and fundus dryness. Although the eye symptoms appear early in most of the diseases, the eye symptoms of older children often appear after other symptoms. 2. Skin manifestations Dry skin, hyperkeratosis and flaking. The keratinized material is filled in the hair follicle cavity and protrudes from the epidermis, so when touched, there are goose bumps or coarse sand-like feeling. The symptoms are most prominent on the extremities and shoulders, and are rare in infants under 4 years of age. In addition, there are also nails with many lines, loss of luster, locust fracture, dry and brittle hair and easy to fall off. 3, other manifestations Due to vitamin A deficiency in the respiratory tract and urinary tract epithelial proliferation and keratinization, as well as immune function decline, easy to cause secondary infections of the respiratory tract and pus urine. Loss of taste buds of the tongue due to epithelial keratinization of taste function, affecting appetite, some children may have vomiting. Delayed physical development is seen in infancy and early childhood. In severe vitamin A deficiency, poor blood cell production and anemia can be seen, and anemia cannot be corrected with adequate iron therapy. Choking has been reported in young infants, and the symptoms are controlled with the addition of vitamin A.