(1) Leflunomide treatment has been used for 6 months on the basis of two tablets (20mg) per day, and continued to take it for 3 months, a total of 9 months, recently checked the liver function, blood indicators are normal; (2) hormone has been used for more than 2 months on the basis of two tablets (10mg) per day, and changed to 4 tablets taken orally every other day, now up to 3 months (2) The hormone was changed to 4 tablets orally every other day for 3 months on the basis of 2 months of hormone use (10mg) per day, for a total of 5 months (in December 2006, the hormone treatment for nephrotic syndrome was started, and different doses of hormone were used uninterruptedly for 3 years. At present, the urine protein has remained negative for 7 months, and in September 2006, a kidney puncture at Peking University Hospital diagnosed mild thylakoid glomerulonephritis. Could you please guide me on the next step: what is the next step to take such drugs as Deflunomide and hormones? Luo Ping, Department of Nephrology, Second Hospital of Jilin University Luo Ping, Department of Nephrology, Second Hospital of Jilin University: Please forgive me for just seeing the posting! Leflunomide is reduced to 10mg (1 tablet) per day, hormone continues to be 4 tablets every other day, pay attention to review urine routine and 24-hour urine protein quantification. Patient: Thank you for your prompt reply, we will use the medication according to your instruction. If the condition continues to improve (urine routine and urine protein quantification are normal), in order to understand the process of treatment, I would like to ask you: (1) How many months does it take to maintain the normal level of leflunomide by reducing it to 10mg (1 tablet) per day? (2) At what point can the hormone be reduced by 4 tablets every other day?