The most common form of familial hypercholesterolaemia, caused by mutations in the low-density lipoprotein (LDL) receptor gene, is inherited in a dominant manner, meaning that the disease can be caused…
Patients with familial hypercholesterolaemia have elevated cholesterol levels due to a genetic defect; patients with common hypercholesterolaemia usually have a metabolic disorder due to an acquired unhealthy lifestyle.Patients with common…
Patients with pure heterozygous familial hypercholesterolaemia usually develop severe cardiovascular disease in childhood and die in their 20s and 30s.Patients with untreated heterozygous familial hypercholesterolaemia also have a significantly earlier…