A sore throat does not usually affect the results of a nucleic acid test. Nucleic acid testing is a more specific and sensitive test. Nucleic acid testing is currently performed primarily for new forms of Crown Pneumonia. If the patient’s sore throat symptoms are caused by a recent upper respiratory tract infection such as a cold, pharyngitis, tonsillitis, etc., the sensitivity of the nucleic acid test is generally not affected. If the patient has any of the above diseases, it is recommended to inform the doctor before the test, and the doctor should be gentle during the sampling process to avoid irritating the congested and swollen pharyngeal mucosa. If the patient has a recent epidemiologic history of neocoronary pneumonia and presents with sore throat symptoms, it cannot be excluded that the patient has contracted a new type of coronary pneumonia. In this case, the patient needs to actively inform the doctor in detail about the history of travel and close contact, and recommend temporary isolation, which needs to be based on the nucleic acid test results to determine whether there is any infection. Tip: In this article, the terms “new coronavirus pneumonia” and “new coronavirus pneumonia” were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.