The difference between herpes zoster and papular urticaria lies in treatment variability, different symptoms, and different causes. 1. Treatment variability: (1) papular urticaria: in case of papular urticaria, anti-allergic and anti-infectious drugs such as zinc oxide ointment or prednisone acetate tablets should be administered under doctor’s supervision. (2) Herpes zoster: Herpes zoster has some limitations and can be treated with antiviral or pain-relieving medications such as acyclovir or pregabalin capsules under doctor’s supervision. Also pay attention to personal hygiene, and develop good personal hygiene habits in daily life. 2. Symptoms are different: (1) Papular urticaria: It usually manifests as red spots the size of pea grains with varying degrees of itching and redness. There is usually no pain. (2) Herpes zoster: the main symptom is pain, and the rash that appears is mainly in the form of papules and blisters, often appearing on the chest and abdomen, head, face and eyes. 3. Different etiologies: (1) papular urticaria: the main cause of papular urticaria is mosquito bites. In addition, it is necessary to change the living environment in time so that the condition can be recovered or terminated in a short time. (2) Herpes zoster: Herpes zoster is caused by varicella-zoster virus, and its cause and pathogenesis are relatively simple. Therefore, prevention should be combined with the cause of the disease in daily life. If the rash can not be distinguished from herpes zoster or papular urticaria, it is recommended to go to the hospital in a timely manner, under the guidance of a professional doctor to clarify the cause of the disease, and timely symptomatic treatment.