Secondary malignant tumor of liver generally refers to metastatic liver cancer. Metastatic liver cancer generally cannot be treated well, but patients can improve the quality of survival and prognosis after relevant treatment. Metastatic liver cancer refers to the spread or metastasis of malignant tumors originated from other organs of the body to the liver. The cause of metastatic liver cancer is mainly that malignant tumors in other parts of the body grow to a certain extent, which will release cancer cells into the circulatory system and eventually enter the liver, forming secondary liver cancer. Generally, metastatic liver cancer cannot be treated well. Patients with metastatic liver cancer can take targeted drugs such as sorafenib, lenvatinib and regorafenib orally under the instruction of doctor. Sub-patients can take lobectomy, segmental resection resection, local and other surgical resection radiotherapy and chemotherapy, which generally have better prognosis and can improve the quality of survival. Chemotherapy drugs include gemcitabine, cisplatin and so on. Once diagnosed with metastatic liver cancer, patients need to actively cooperate with doctors to take relevant treatment measures and follow doctor’s prescription to avoid delaying the condition. In daily life, patients should ensure enough sleep and do not overwork.