Gastric pathology biopsy of highly suspicious tumor lesions can be chosen according to the situation to add immunohistochemistry and other tests, re-biopsy and other methods to help diagnose the nature of the lesion, if the diagnosis of malignant can be based on the staging of the choice of surgery, radiotherapy and other methods of treatment, if the diagnosis of benign can be endoscopic treatment and regular review. 1. Additional examination: highly suspicious tumor lesions are mostly diagnosed by pathologists under ordinary microscope, when ordinary HE staining can not determine the nature of the tumor, further examination such as immunohistochemistry can be done according to the requirements of pathologists to help determine the nature of the lesion. 2. Re-biopsy: some pathology examination can not make accurate judgment because of less biopsy tissue, it can be re-biopsied to get more tissues for further examination and judgment. If there are obvious metastases in perigastric lymph nodes or distant metastases in liver or lungs in some patients with highly suspicious tumorous lesions in stomach, pathological biopsy of metastatic foci can be performed to determine the nature of the disease and make a clinical diagnosis. If the diagnosis is malignant through the above methods, treatment such as surgery, radiotherapy, chemotherapy, etc. can be selected under the guidance of the doctor according to the specific stage, and if it is determined to be benign after sufficient evaluation, endoscopic treatment can be followed by regular review and follow-up according to the doctor’s instructions. If there is any discomfort, consult a doctor in time and follow the medical advice.