The American College of Gastroenterology has released a new evidence-based medical guideline on the diagnosis and treatment of focal liver lesions (FLLs), which was published online in the Aug. 19 issue of the American Journal of Gastroenterology. The guideline is intended for gastroenterologists and is designed to facilitate and improve patient care. The key recommendations are compiled below. 1. suspected hepatocellular carcinoma 2. suspected cholangiocarcinoma 3. suspected hepatocellular adenoma 4. suspected hemangioma 5. suspected focal nodular hyperplasia (FNH) 6. suspected nodular anaplastic hyperplasia 7. suspected simple hepatic cyst 8. suspected cystic adenoma or cystic adenocarcinoma of the bile ducts 9. suspected cystic liver 10. suspected cystic cyst of the liver Remarks: BC, cystic adenoma of the biliary tract; BCA, cystic adenocarcinoma of the biliary tract; CCA, cystic adenocarcinoma of the biliary ducts; CCA, cholangiocarcinoma of the biliary ducts. cystadenocarcinoma; CCA, cholangiocarcinoma; CT, computed tomography; FLL, focal liver lesion; FNH, focal nodular hyperplasia; HCC, hepatocellular carcinoma; IUD, intrauterine device; MRI, magnetic resonance imaging; NRH, nodular regenerative hyperplasia; OCP, oral contraceptive pills; PAIR, puncture, aspiration, injection, and resorptive; US, ultrasonography.