HPV is human papillomavirus vaccination (HPV for short), is a large family with more than 130 subtypes, distributed in many parts of the body of the skin and mucous membranes, both male and female, the most common is the oropharynx, anogenital tract. Of the HPV subtypes that grow in the mucous membranes, more than 40 are associated with genital tract infections.HPV is categorized into high-risk and low-risk types, and persistent high-risk viral infection is the most important causative factor leading to squamous carcinoma of the cervix and its precancerous lesions, with high-risk viral infections being present in virtually all (>99.9%) of lesions.The majority of oropharyngeal tumors (63%) have a high risk of infection. Most oropharyngeal tumors (63%) and almost all anal cancers are also associated with persistent infection with high-risk HPV. The specific high-risk HPV types remain controversial, with some suggesting as many as 15 or 16, of which WHO has identified 13 as having the most oncogenic potential: types 16, 18, 31, 33, 35, 39, 45, 51, 56, 58, 59, and 68 [4]. Of these, HPV 16 and HPV 18 cause 70% of cervical cancers, while HPV 45 and HPV 31 cause 5% and 10% of cervical cancers, respectively. Low-risk viruses are pathogens that cause perianal warts of the genital tract and include HPV types 6, 11, 40, 42, 43, 44, 53, 54, 61 and 72. Of these, HPV 6 and HPV 11 alone are associated with 90% of genital tract warts and 96% of condyloma acuminatum, but do not cause cancer. Some people think that cervical precancerous lesions and cervical cancer go through the “warts” stage, which is a joke, not understanding the classification and typing of HPV. 1, HPV infection is very common, transmitted through sexual behavior: Human papillomavirus (HPV) is the most common type of pathogen transmitted through sexual intercourse, and the prevalence of HPV infection worldwide is as high as 10% [5]. Infection rates are particularly high in young women (45% of women aged 20-24 years in the United States) and decline sharply after the age of 30 years [6]. For this reason none of the large medical guidelines recommend HPV testing routinely in women under 30 years of age. The lifetime risk of HPV infection is about 80%, and it is estimated that about half of all men and women have been infected with HPV once in their lifetime [7]. Confirmed modes of transmission are mucous membrane-to-skin and mucous membrane-to-mucous membrane direct contact, including vaginal, anal, and oral sexual intercourse, and there is limited evidence as to whether HPV can be contracted by other modes, and it is not possible to open one’s eyes to the possibility of HPV infection. The suggestion that you can easily get warts from wearing an ultra-short skirt on a bus is also a joke, and an obscene one at that, and has been refuted in the professional literature and in the serious media. HPV is highly contagious compared to human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2), which are pathogens with lower transmission rates. With each sexual encounter, the transmission rate from male to female is as high as 0.4 to 0.8. Each male sexual partner has a 60 to 80 percent chance of transmitting HPV16 to a woman. Any factor related to sexual activity is a high risk factor for HPV infection of the genital tract, including younger age at the start of sexual intercourse, number of sexual partners, recent changes in sexual partners, and sex with someone who has another sexual partner (both male and female) [8]. HPV infection is so common in both men and women that hospitals would be overcrowded if everyone sought treatment. Those peddling “HPV removal drugs” business is not laughing mad? 2, the vast majority of HPV infections can be cleared in a relatively short period of time The vast majority (more than 95%) of genital HPV infections are benign and can be cleared on their own, with only a small percentage of women becoming persistently infected. The vast majority (more than 80%) of HPV infections clear within a few months (usually within 6-9 months, with an average of 8 months, and rarely more than a year), 87% of HPV infections clear within 12 months [9], and 95% clear within 2 years [10-13]. HPV typing is the most important factor determining persistent infections, and factors such as age and sexuality have no significant effect. did not have a significant effect. The time course of HPV infection also varies by type. High-risk viruses seem to persist in infection longer (median 9.3 months) than low-risk HPV (median 8.4 months.) HPV16 is the most likely to persist in infection (median 12.4 months), but the exact reason for this is unclear and may be related to the immune mechanism of the body [14-17]. It has been claimed that the application of nucleoside antivirals can convert 85% of patients within six months, for which no evidence is known. Even if it is true, it is not as brilliant as it could be. This is because doctors who really know the natural history of HPV do not go back and forth to check for HPV within six months. It is the persistent high-risk type of HPV infection that is likely to lead to the development of cervical precancerous lesions (cervical intraepithelial neoplasia). One study found that after a median of 33 months of follow-up, 9.3 percent of women with persistent high-risk HPV infection developed cervical intraepithelial neoplasia grade 3 lesions. The progression from precancerous lesions to invasive cervical cancer is long, and formal screening detects the vast majority (>99.7%) of lesions during this long progression [18, 19], which is one of the reasons for the decline in the incidence of cervical cancer in developed countries. We are also paying increasing attention to persistent high-risk HPV infection, but the emphasis is on practical prevention and screening [19]. Because there is no treatment that can completely clear HPV infection. 3, there is no treatment that can completely clear HPV infection There is no effective antiviral treatment for either high-risk types of HPV or low-risk types of HPV, only for lesions caused by HPV, such as warts of the genital tract and anus, such as precancerous lesions, such as cancer. This has been demonstrated by a large number of studies [20-22]. There can be many symptomatic treatment options for warty lesions of the genital tract and anus (e.g., condyloma acuminatum) (cryotherapy, laser, interferon, antiviral drugs, immunotherapy, etc., etc.), but there are still no effective measures or drugs to clear the virus [20-24]. Some people may emphasize that these studies are foreign and cannot represent the Chinese people, who have a physique rich in Chinese characteristics. Well, to date, there is no published literature in mainland China that shows any surgery or drug to clear HPV infection. Studies from Taiwan have also found that topical medications do not clear HPV infections at a rate somewhat faster than the natural clearance rate [25]. Well, Taiwan is an integral part of China, too! Based on these realizations, all of the slightly more serious articles will not recommend the application of any surgery or medication for the treatment of HPV infection, let alone solemn evidence-based academic guidelines. The fact that there is no cure for the removal of HPV is not a particularly depressing thing; it is the current state of all viral treatments. We currently have no cure for any of the human viruses, such as hepatitis, such as HIV, such as SARS, and we can’t even eliminate the cold virus. Some have compared viral infections of the cervix to viral infections of the throat, and there is truth in that. 4. For lesions caused by high-risk HPV infection, HPV vaccination and regular screening are emphasized For pre-cancerous lesions and cancers caused by high-risk types of HPV, firstly, HPV vaccination is recommended [26-28], and secondly, regular and formal screening and diagnosis and treatment are emphasized [29-34]. Both issues are important, so important that there is too much to say for this small article to accommodate. HPV vaccines are currently available for two, four and nine subtypes of HPV [35-37]. However, there is no HPV vaccine on the market in the Mainland, and screening and diagnosis are even more chaotic, with sensationalized unnecessary diagnosis and treatment and over-diagnosis everywhere. The country is in a state of flux, and the waves are still in the air. Due to the high clearance rate of HPV, the rarity of persistent infection, and the excellent prognosis of low-grade cervical lesions, simple HPV infection or even low-grade precancerous lesions (i.e., cervical intraepithelial neoplasia grade 1 (CIN1)) can be conservatively observed and followed up [38], while CIN2 or more serious lesions (e.g., cancers) need to be treated at a formal healthcare center by an experienced gynecologic oncologist. gynecologic oncologist for help. This is a much larger topic. Many people believe that HPV infection is a direct result of “dirty sex” and therefore needs to be treated! The question is, what does it mean to have “unclean sex”? Ignoring the ignorance of the subject matter of this view, the righteous face of moral judgment is laughable. “HPV infection is not an absolute marker of ‘fidelity’ between sexual behaviors and sexual partners.” “Disease is not God’s punishment of man. Although the occurrence of disease is closely related to human behavior. People with any kind of disease should be treated with compassion, care and healing, or at least, doctors should be.” The twisted morality of HPV infection and cervical cancer is just one of the dark sides of our society.