Late symptoms of nodular itchy rash include hemispherical nodules, marked keratinization on the top as well as intense itching and mossy changes. Nodular itchy rash is a chronic, inflammatory skin disease, the cause of which is not yet clear, and may be related to insect bites, gastrointestinal disorders, endocrine disorders and other factors. Nodular itchy rash at the beginning of the manifestation of the needle cap to the size of rice grains of light red papules, but with the growth of time, will gradually grow to mung bean to soybean size, the late manifestation of hemispherical, solid elevated pimples, nodules, the tip of the keratinization is more pronounced, more wart-like appearance, rough to the touch, the performance of the yellowish-brown, grayish-brown, and so on. In addition, the skin around the nodules will have hyperpigmentation, thickening and mossy changes, preferably on the limbs, often accompanied by intense itching. If the above symptoms occur, it is considered that nodular itchy rash has entered the advanced stage, and it is recommended that the patient go to a regular hospital to standardize the diagnosis and treatment.