The choice between Ebastine and Cetirizine for the treatment of itchy nodular rash should be individualized, there is no such thing as which one is more efficacious, so please follow your doctor’s instructions and standardize your treatment. The treatment of itchy nodular rash depends on the intensity of the itching, age, comorbidities, severity, impaired quality of life and the expected side effects of the treatment. The main principles of nodular itch treatment are anti-inflammatory and relief of itching. 1. Efficacy: Ebastine tablets belong to the highly selective peripheral H1 receptor antagonist, can inhibit the rash caused by histamine, with rapid and long-lasting histamine inhibition. And cetirizine mainly through the inhibition of histamine transmission and action, and inhibit the vasoactive peptide and substance P in the metamorphosis, reduce the movement of inflammatory cells, so as to improve the itching and rash symptoms. Both drugs can be used for nodular itchy rash treatment. 2. On side effects: for ebastine tablets the main side effects are reactions in the digestive tract, which can be seen as stomach upset and sometimes abnormal liver function. Allergic to this drug is prohibited. The main side effects of cetirizine are dizziness, drowsiness, sleepiness, dry mouth and so on. It is contraindicated in people who are allergic to this drug and have severe renal insufficiency. Patients should choose to use the drug under the guidance of the doctor, do not blindly take it to cause adverse consequences.