Nodular itchy rash belongs to the chronic inflammatory skin disease, mainly characterized by severe itching and nodular damage, can cooperate with the doctor to choose topical glucocorticoid drugs, calcium-modulated phosphatase inhibitors and keratolytic agents and other treatments. 1. Glucocorticoid: For nodular itchy rash, you can cooperate with your doctor to choose topical glucocorticoid treatment, such as halometasone, compound flumethasone, halometasone triclosan and so on. If necessary, you can inject compound betamethasone injection into the skin lesions. 2. Calcium-modulated phosphatase inhibitors: such as tacrolimus, pimecrolimus and other drugs, also has the effect of anti-inflammatory, improve itching, promote the lesions to subside. 3. Keratin exfoliators: such as salicylic acid ointment and other drugs, can promote exfoliation, promote skin lesions subside. It is recommended to use medication under the guidance of a doctor, not blindly self-medication to avoid adverse effects.