Corticosteroid therapy The mechanism of action of hormone therapy for vitiligo may be related to the immunosuppressive effect of hormones; it is also believed that hormones themselves can act directly on melanocytes and can induce melanin synthesis. Systemic hormone therapy is often used for patients with generalized or progressive vitiligo, especially for patients with rapid development under stress or with autoimmune diseases. Method: Take 15mg of prednisone orally in the morning, and then decrease 5mg per month until 5mg per day for 3-6 months. The small dose of hormone is effective in preventing the progression of the disease with no significant adverse effects, and can restore the skin color of patients with progressive vitiligo.