Liver puncture biopsy is the gold standard for the diagnosis of cirrhosis. However, it is an invasive procedure that requires a liver puncture to remove liver tissue for this test. Most patients are reluctant to undergo this test. Other than liver biopsy, what clinical tests are useful in determining cirrhosis? Comprehensive indicators that often help to diagnose cirrhosis include the following five items: a. Blood count (if white blood cells and platelets are below normal values, it indicates hypersplenism, suggesting a high probability of cirrhosis). Liver function items: 1, the ratio of liver enzymes, AST/ALT, if the ratio of these two enzymes > 1.0, suggesting cirrhosis, but to exclude the influence of enzyme-lowering drugs, people who drink more AST/ALT also > 1.0; 2, long-term mild to moderate elevation of bilirubin, especially indirect bilirubin is predominantly elevated, often cirrhosis decompensated stage. However, we should pay attention to individual patients with congenital jaundice (gilbert syndrome) when the indirect bilirubin in blood can be elevated for a long time or repeatedly, this situation can not be diagnosed as cirrhosis; 3, serum protein: albumin (A) is reduced, globulin (G) is elevated, A/G inversion (<1.0), suggesting cirrhosis; 4, GGT is elevated (in early cirrhosis, this enzyme can be elevated, but many other 4, GGT is elevated (in early cirrhosis, this enzyme can be elevated, but many other causes can also be elevated, such as biliary sludge, cancer of the liver and biliary tract, long-term alcohol consumption). Elevated serum fibrosis markers (HA LN PCIII CIV) have some reference significance, but cannot be used as an important basis, because clinical studies have shown that elevated serum fibrosis markers are often inconsistent with the pathological findings of liver penetration. For example, ultrasound indicates large spleen, widened portal vein, disproportion between the left and right lobes of the liver, coarse liver mass or small nodules, etc. These signs are likely to have cirrhosis of the liver. Five, liver fibrosis scan (Fibroscan), has a reference value, but can not be used as a basis for diagnosis, and many primary hospitals have not yet carried out this test. Clinically, the above-mentioned indicators should be considered together in order to reach a more accurate conclusion.