The National Comprehensive Cancer Network (NCCN) publishes annual clinical practice guidelines for various malignancies that are recognized and followed by clinicians around the world. NCCN is a non-profit academic alliance of 21 top cancer centers in the world, and the NCCN Clinical Practice Guidelines in Oncology developed by NCCN is not only the standard for clinical decision making in the field of oncology in the United States, but also has become the most widely used guideline in global oncology clinical practice, and has been recognized and followed by oncologists in China. Due to the differences in patient characteristics, medical level and system, it is still difficult to apply the guidelines directly in China. In view of this, NCCN has worked closely with Chinese oncologists to develop a Chinese version of the NCCN guidelines that meets the needs of the Chinese population. Liu Puxiang, Department of Medical Oncology, Affiliated Hospital of Shandong Academy of Medical Sciences Under the initiative of Professor Sun Yan, the first “Chinese and foreign consensus meeting on NCCN clinical practice guidelines for non-small cell lung cancer and breast cancer” was held in Beijing in 2006. Based on thorough discussions, Chinese experts and NCCN experts jointly developed the “NCCN Clinical Practice Guidelines for Breast Cancer (Chinese version)” and “NCCN Clinical Practice Guidelines for Non-Small Cell Lung Cancer (Chinese version)”. The release of these two Chinese versions of the guidelines has been recognized by the majority of oncologists, who have expressed their desire to see more NCCN guidelines in China. In 2007, NCCN collaborated with Chinese experts again and revised the Chinese version of NCCN guidelines for non-Hodgkin’s lymphoma, gastric cancer and colon cancer for the first time, in addition to updating the NCCN Clinical Practice Guidelines for Breast Cancer (Chinese version) and NCCN Clinical Practice Guidelines for Non-Small Cell Lung Cancer (Chinese version). Currently, the latest version of the NCCN (China version) covers tumors including: non-small cell lung cancer, breast cancer, non-Hodgkin’s lymphoma, colon cancer, gastric cancer, rectal cancer, cervical cancer, ovarian cancer, kidney cancer, and head and neck tumors in a total of ten common malignancies. Every year around October, CSCO expert groups refer to the international NCCN and combine the characteristics of comprehensive cancer treatment in China to develop and publish clinical practice guidelines that meet the needs of Chinese patients. NCCN guidelines update NCCN clinical practice guidelines for oncology are developed by 47 expert committees. Their membership is comprised of nearly 950 practicing clinicians and oncology researchers from 23 member institutions. The annual review agenda for each cancer practice guideline will ensure that the content is current.