Patients who have pain in the corner of the eye after closing their eyes may be caused by foreign bodies, blepharitis and other diseases, and patients should consult a doctor in time to clarify the cause of the disease and then treat it. 1. foreign body: patients with pain in the corner of the eye after closing the eyes, may be the corner of the eye caused by a foreign body, because the foreign body into the corner of the eye tissue, the patient blinking after the pain can occur. 2. Blepharitis: blepharitis refers to purulent inflammation of the eyelid glands, patients may have redness and swelling of the eyelids, and patients may experience increased pain after stimulating the redness and swelling when the eyes are closed. Patients can use erythromycin ophthalmic ointment, tobramycin ophthalmic ointment and other medications as prescribed by the doctor to control inflammation and promote recovery. It is recommended that patients who experience pain in the corner of the eye after closing their eyes should seek prompt medical attention to assess their condition and follow the doctor’s instructions for treatment.