Patients rubbing the corner of the eye pain, may be visual fatigue, conjunctivitis, blepharitis and other diseases caused by the patient can consult a doctor in time to clarify the cause of treatment. 1. Visual fatigue: If the patient stays up late for a long time and stares at the electronic equipment for a long time, the pain in the corners of the eyes after rubbing the eyes may be caused by visual fatigue, and the patient may experience tearing, dry eyes, acidity and other uncomfortable symptoms. Patients should pay attention to rest, if necessary, the use of artificial tears for treatment, such as sodium vitrate eye drops. 2. Conjunctivitis: bacteria, foreign bodies and other causes of conjunctivitis, under the stimulation of inflammation, the patient rubbing the eyes can appear corner of the eye pain, the patient can appear tearing, eye redness and swelling and other symptoms, the patient can follow the doctor’s instructions to use levofloxacin eye drops and other drugs to treat, to relieve the discomfort of the eye. 3. Blepharitis: Blepharitis refers to purulent inflammation of the eyelid glands, and patients may experience pain in the corner of the eye after rubbing their eyes, and patients may experience localized redness, swelling, and warmth of the eyelid and other uncomfortable symptoms. It is recommended that patients with significant pain in the corners of the eyes should seek prompt medical attention to assess their condition and follow the doctor’s instructions for treatment.