Leukopenia, what is leukopenia? What are its clinical manifestations? Also how is it treated? This is the most important question for patients and their families. And from the doctor’s perspective, what do we care about? How do people properly understand leukopenia? Below we briefly outline leukopenia. I. What is leukopenia and how is it generally treated? Leukopenia is defined as leukopenia when the peripheral blood count is less than the normal reference value (usually less than 4*10e9/L). It is mainly neutropenia, which is generally defined as less than 2*10e9/L. Therefore, it is advisable to check the neutrophil count of routine blood/blood cell analysis results. Clinical leukopenia has no specific manifestations, and is generally found by routine blood tests in the majority of patients with leukopenia. Patients are mostly seen with tiredness, dizziness and discomfort, easy to catch a cold and fever, sore throat, and even high fever.
Neutropenia can be briefly divided into three degrees: (1) less than 0.5*10e9/L is the granulocyte deficiency stage, it may lead to serious infections, and even life-threatening, should be hospitalized to clarify the cause and treatment of the cause based on active leukocyte treatment, such as fever should be given empirically broad-spectrum bactericidal antibiotics; (2) 0.5-1*10e9/L is moderate granulocytopenia (3) 1-2*10e9/L is mild granulocytopenia, which is comparable to the chance of infection in normal people, so it is not necessary to actively raise leukocytes for the time being, and attention should be paid to investigate the cause of leukopenia and treat the cause. Second, the diagnostic thinking of leukopenia When a patient with leukopenia is seen, we often have to consider its authenticity. If it is not a test error, what is the cause of leukopenia?
1. Analysis of the metabolic process of leukocyte production: (1) too little production: such as bone marrow hematopoietic defects resulting in too little production: hypoproliferative leukemia, aplastic anemia, myelodysplastic syndrome, etc.; insufficient hematopoietic materials such as megaloblastic anemia, etc.; (2) too much destruction: such as rheumatic immune diseases, etc.; 2. (2) other systemic diseases: such as connective tissue diseases, autoimmune diseases, severe infections, etc.
Therefore, there are various causes of leukopenia, so we do not need to worry too much or take it too lightly, but should be examined as soon as possible and treated according to the condition.