The main types of anti-allergic drugs taken for hives are antihistamines, glucocorticoids, and drugs that reduce vascular permeability. Patients in addition to medication should also be timely to find the cause of the disease, especially to find the rapid triggers of the disease in order to reduce the degree of skin vasodilatation. 1. Antihistamines: the effective treatment of urticaria is the first and second generation antihistamines, the current clinical mainly the second generation of antihistamines as a first-line drugs, because the first generation of antihistamines will cause patients with varying degrees of drowsiness, and severe cases may have cognitive impairment. Second-generation antihistamines mainly include cetirizine, levocetirizine, and desloratadine. If the efficacy of the second generation is not good, the first generation antihistamines can be added as an adjunctive therapy, and in order to minimize the effects of adverse reactions, a single dose can be given in the evening. If the second-generation antihistamines alone are ineffective in the treatment of chronic urticaria, the following drugs can be combined: H2 receptor antagonists, such as ranitidine, cimetidine; stabilization of mast cell membranes, inhibition of mast cell release mediators, such as trinitrotoluene, ketotifen; leukotriene receptor antagonists such as montelukast and so on. 2. Glucocorticoid: as the second-line urticaria treatment drugs, the main indications for antihistamine treatment is ineffective acute urticaria, urticarial vasculitis, etc.. 3. Drugs to reduce the permeability of the blood vessel wall: mainly vitamin C, calcium, can be used together with antihistamines. It is recommended that patients go to the hospital in time according to the symptoms, and use medication under the guidance of the doctor, do not do it on your own.