Rheumatoid arthritis and ankylosing spondylitis are autoimmune diseases whose causes are still unknown. 2, taking hormonal drugs such as prednisone, prednisone, dexamethasone, etc.. These drugs also cannot prevent or slow down joint deformation, and generally after five or ten years of taking them, patients may still have joint deformation or even paralysis. Moreover, taking hormonal drugs for a long time can greatly increase a patient’s risk of osteoporosis and fractures, and aggravate diseases such as diabetes and hypertension. In the past, hormones were commonly used in the treatment of juvenile rheumatoid arthritis and ankylosing spondylitis. As a result, the growth and development of many juveniles stopped, and they could not grow taller or bigger. 3.Take methotrexate, lorazepam and other slow-acting anti-rheumatic drugs These drugs are slow to take effect (usually take 3-6 months to take effect), although they can effectively improve the disease, slow down and prevent joint deformation, but not every patient will have a significant effect on every drug. It is necessary to find out which drug is effective for each patient and what dose is appropriate for him. At the same time, these drugs have certain effects on the blood and liver system, so regular check-ups are required during the drug taking period. 4, biological agents treatment can not only effectively prevent the occurrence of joint and spine destruction and deformation, but also much better than the conventional use of chemical drugs in the past, but also much safer, with much less side effects. The therapeutic effect of these biological agents is like a “targeted blast” or “biological missile”, which “blows up” the tumor necrosis factors and stops them from transmitting the disease. The effect of these biologics is like a “targeted blast” or “biological missile”, which “blows up” the tumor necrosis factors, stops them from transmitting the disease “fire” and makes the disease spread, thus the disease activity in the patient’s body can be controlled more easily. However, modern biological agents are still ineffective in repairing joints and spines that have already undergone deformation and disability, and better results can only be achieved by treatment in the early stages of the disease, before the destruction and damage to the skeletal structure of the joints occurs. It is generally believed that the best time to treat the disease is during the first six months to a year after the onset of the disease. Medical research has proven that if biologics are given during this optimal treatment window for six months to a year, a small percentage of patients can be treated for more than three years without medication or injections, and arthritis and spondylitis will not recur, achieving the so-called “cure for the root of the disease”. These biologics have been a boon especially for adolescents with rheumatoid arthritis and ankylosing spondylitis, allowing them to be cured without hormones.