Pneumonia 13-valent vaccine is usually administered once in the 2nd, 4th and 6th months of life, and can be boosted once more at the age of 12-15 months to enhance the preventive effect. Streptococcus pneumoniae is mainly spread through respiratory droplets, or when the immune system is lowered, colonized Streptococcus pneumoniae invades the mucous membrane of the lungs, thus inducing diseases such as pneumonia and bronchitis, which can be effectively prevented by 13-valent pneumonia vaccine. In addition, there may be adverse reactions to pneumonia 13-valent vaccination, including redness, swelling, pain and fever at the vaccination site, etc. If the adverse reaction is severe, it is recommended to seek medical attention.