During the treatment of pneumonia, there may be a situation where the symptoms become more severe the more you treat the infection. This is often due to specific bacterial infections, multi-drug resistant bacterial infections, or failure to select the appropriate antibiotic for the causative agent of the infection. For example, for patients with Gram-positive coccus infections, we generally need to choose first- and second-generation cephalosporins, and if a third-generation cephalosporin is chosen at this time, the efficacy may not be particularly obvious. There are also many bacteria that have mutated with the use of antibiotics, and there are more resistant groups of bacteria, which is also a difficulty in the treatment of pneumonia. The first thing is to adjust the medication in time if there is no significant improvement in the process of pneumonia treatment, and secondly, to choose broad-spectrum, targeted drugs for treatment according to the results of bacterial culture and drug sensitivity tests.