Pioglitazone hydrochloride tablets have the potential to cause hematuria. 1. Pioglitazone Hydrochloride Tablets is a glucose-lowering drug of the glitazones class, which is an insulin sensitizer. This product is used in patients with type 2 diabetes mellitus, and it may be used in conjunction with dietary control and physical exercise to improve and control blood glucose. It can be used alone or in combination with sulfonylureas, metformin or insulin when dietary control, physical activity and monotherapy fail to control blood glucose satisfactorily. 2. Long-term use of pioglitazone is associated with an increased risk of bladder cancer, so it is not possible to completely rule out whether the development of hematuria in patients taking pioglitazone hydrochloride tablets is related to the development of bladder cancer. Therefore, it is recommended that patients who develop hematuria should go to the hospital in time to have the cause clarified. Pioglitazone hydrochloride tablets must be used strictly under the supervision of a physician, and if hematuria or other abnormal adverse reactions occur after use of the drug, the drug should be immediately discontinued and the physician should be informed.