“Systemic lupus erythematosus is a “systemic autoimmune disease”. The main role of the immune system is to destroy foreign invaders such as bacteria and viruses, and to remove abnormal tissue cells from the body, among other things. However, when the immune system is disrupted for some reason that we do not fully understand, our own normal tissues should be attacked by the immune system and become diseased. This is called “autoimmune disease”. If several organs and tissues in the body are attacked by the immune system, causing damage and complicated clinical manifestations, and a large amount of “autoantibodies” can be detected in the blood, we may have what is currently called “systemic lupus erythematosus”. In fact, the name “SLE” does not accurately reflect the characteristics of this disease, but it is easy to think that it is a contagious skin disease. The name of the disease is a visual reflection of the process of human understanding of the disease: initially, doctors observed a skin disease that resembled the bite of a wolf and named it “lupus”; later doctors found that the skin changes of “lupus” could include Later, doctors found that the skin changes of “lupus” could have various skin manifestations such as “erythema”, so the name “lupus erythematosus” appeared; later, doctors found that “lupus erythematosus” could damage joints, kidneys, brain, heart and lungs in addition to skin lesions. Later, doctors found that in addition to skin lesions, “lupus erythematosus” could also damage joints, kidneys, brain, heart, lungs and other organs and tissues of the whole body. After the 1950s, a large number of “antibodies (normally against “foreign invasion” and abnormal tissue cells)” were found in the blood of these patients against their own normal tissue cells, and since then, it can be said that the understanding of “systemic lupus erythematosus” has been improved. Since then, a qualitative leap has been made in the understanding of “SLE”. Recognizing that it is an autoimmune disease, the use of immunosuppressants became inevitable, and it is with the use of immunosuppressants that SLE is no longer an incurable disease that people talk about. We are now able to control the disease in the majority of patients, allowing them to live (including childbirth), study, work, and age normally. Of course the prerequisite for this at present is; timely detection of the disease, long-term regular observation and treatment. Unfortunately, due to insufficient awareness, many patients do not receive timely diagnosis and treatment in the early stages of the disease, but are only discovered in the later stages of the disease when serious damage to organ function occurs and treatment is ineffective. Therefore early detection is crucial. So, what are the conditions that need to be noted as having the possibility of this disease? Generally speaking, one of the following manifestations should be noticed, and it is more likely if more than one occurs at the same time: 1. typical skin damage (see Figure 1-2), skin allergy to sunlight, other unexplained chronic skin damage; 2. recurrent oral ulcers; 3. severe hair loss – lupus hair (dry, easily broken, falling off in patches); 4. joint swelling and pain; 5. flushing, whitening, tingling when the fingers or toes are cold Fever of unknown origin; 8. Unexplained organ tissue lesions: anemia, thrombocytopenia, leukopenia, proteinuria, edema, pneumonia, pleural effusion, liver, brain, heart and other organ lesions; Figure 1-2 Lupus erythematosus Typical “butterfly-shaped erythema” Figure 1 Figure 2 Figure 3-4 Raynaud’s phenomenon Figure 3 Figure 4