Patients with SLE have normal fertility, but patients (especially those with positive anti-ACL antibodies) are prone to miscarriage, preterm delivery, stillbirth, and intrauterine fetal dysplasia after pregnancy, and the incidence of abnormal pregnancy is higher in patients with active SLE, and pregnancy can trigger SLE, aggravate the disease, or cause relapse of the disease. The current consensus is that after pregnancy, about 50% of SLE patients have aggravated their disease, and the deterioration of the disease is more significant in those with active primary disease, even in the stable stage of pregnancy, 10%-30% of patients have aggravated their disease during pregnancy or after delivery, and some patients have developed nephropathy or aggravated their existing nephropathy during pregnancy, and even induced renal failure. The effect of pregnancy on SLE may be related to the increase of estrogen level in patients during pregnancy. Therefore, it is currently advocated that patients with active SLE should not be pregnant. Patients whose disease has been stabilized for more than one year with oral prednisone tablets at 15mg|d or less may be considered for pregnancy.