Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple systems and organs, with a complex clinical presentation and a recurrent disease course. It most often affects women of childbearing age. Systemic lesions may be present. The disease may present with recurrent high fever or prolonged low fever, butterfly-shaped erythema or discoid erythema on the cheeks, punctate bleeding, erosions or ulcers on the oral mucosa, and swollen, aching joints. SLE can also present with pleurisy, pericarditis, nephritis, neurological damage, hematological damage, digestive system symptoms and other lesions of varying degrees. Currently, the classification criteria revised by the American College of Rheumatology in 1982 are usually used: 1. facial butterfly erythema; 2. discoid erythema; 3. sunlight sensitivity; 4. oral or nasopharyngeal ulcers; 5. non-erosive arthritis; 6. plagiocele; 7. renal damage; 8. neuropathy: seizures or psychosis; 9. hematologic abnormalities: hemolytic anemia, leukopenia, lymphopenia, or thrombocytopenia 10. immunological abnormalities: positive lupus cells, positive anti-ds-DNA antibodies, positive anti-SM antibodies, or false-positive anti-syphilis serologic test lasting 6 months; 11. positive antinuclear antibodies. Clinically, SLE can be diagnosed if 4 or more of the above 11 criteria are present, provided that other diseases are excluded, but the diagnosis of SLE is more complicated and must be confirmed by a specialist in a regular hospital, and cannot be diagnosed by oneself to avoid misdiagnosis and mistreatment.