Lung cancer related markers mainly include CEA, Cyfra21-1, CA125, SCCA, NSE, ProGRP, CA125, Cyfra21-1.
1.CEA: Lung adenocarcinoma has a high rate of CEA positivity. In the lung adenocarcinoma group, serum CEA level is positively correlated with the stage of the disease, and still has important clinical value in the differential diagnosis of lung cancer.
2. Cyfra21-1: mainly distributed in alveolar epithelium. In lung cancer, cancer cells release Cyfra21-1 into the bloodstream, causing elevation of Cyfra21-1 in serum.
3. NSE (neuron-specific enolase): the preferred marker for detecting small cell carcinoma, most small cell carcinoma patients have elevated NSE.
4. CA125: Lung cancer serum CA125 level is significantly higher than that of benign lung disease group and healthy control group, which is important in the diagnosis and differential diagnosis of lung cancer.
5. ProGRP: Elevated levels of ProGRP can be seen in many tumors of neuroendocrine origin, including non-small cell lung cancer, breast cancer, cervical cancer, hepatocellular carcinoma, medullary carcinoma of thyroid, and so on.
6. SCC-Ag: It is a glycoprotein secreted by non-small cell lung cancer, especially squamous lung cancer. Although the sensitivity is low, it can be used as an auxiliary diagnosis of lung cancer.
At present, there is no single tumor marker that can specifically diagnose lung cancer, but the above tumor markers have certain reference value for the confirmation of lung cancer diagnosis and prognosis evaluation.