The latest survey results show that colorectal cancer ranks the 3rd in incidence of malignant tumors and the 4th in mortality, and how to carry out reasonable and standardized comprehensive treatment according to different conditions is the key to determine the success or failure of colorectal cancer treatment. I. Surgical treatment: At present, the treatment of colorectal cancer is still a comprehensive treatment mainly based on surgery, and the good or bad surgery directly affects the effect of the whole treatment. Nowadays, “minimally invasive surgery” and “massively invasive surgery” coexist, that is, different surgical methods are adopted according to the stage and size of tumor. For early stage and small tumor, laparoscopic surgery can be performed to remove the tumor with less trauma and faster recovery, while for progressive colorectal cancer, open surgery is the main treatment, which is relatively less invasive than “mega surgery”. Since lymph node metastasis is the main cause of colorectal cancer, surgery should not only remove the primary lesion, but also thoroughly remove metastasis and potentially metastatic lymph nodes. For those patients with advanced disease, the problem should be solved by extended radical surgery or simultaneous resection of the involved organs. Only by ensuring sufficient lymphatic clearance can accurate staging be achieved to provide a reliable basis for further treatment. Inaccurate or unreliable staging may result in over-treatment of early-stage patients and under-treatment of late-stage patients, resulting in both economic waste and increased patient suffering. Therefore, standardized radical surgical procedures, i.e. standardized lymph node dissection, are fundamental to the treatment of colorectal cancer. The large number of case reports shows that standardized radical surgery for colorectal cancer has greatly improved the survival rate of patients, and chemotherapy: the efficiency of chemotherapy for colorectal cancer is 30%-40%, not every patient with colorectal cancer needs chemotherapy. Accurate pathological staging after surgery is essential for deciding whether chemotherapy should be given. For those with late stage and difficult surgical resection, preoperative chemotherapy can be considered. The advantage is that it can achieve the purpose of stage reduction, and at the same time, because the tumor still exists, it can directly reflect the sensitivity of the tumor to drugs, which is a popular practice abroad. Radiotherapy: Pre-operative radiotherapy can achieve the purpose of stage reduction and create conditions for surgical radical treatment, and at the same time can reduce tumor inoculation and local recurrence during surgery and increase the possibility of anal preservation. For those tumors with deep local infiltration and extensive lesions, it is expected that surgery cannot achieve radical cure, preoperative radiotherapy can be used to make the tumor smaller, so as to achieve the purpose of radical cure. Postoperative radiotherapy is mainly aimed at those patients with deep local infiltration and cannot be completely removed locally through surgery, in order to reduce postoperative local recurrence and metastasis, which is a supplement to surgery. Other methods: Besides traditional Chinese medicine, emerging immunotherapy has been applied and immunochemotherapy may be introduced as adjuvant treatment for colorectal cancer in the future. Targeted drugs (e.g. Avastin, C225), as a new class of more effective and less toxic drugs, are under clinical trials for adjuvant treatment and will be widely used in the clinic in the near future.