To date, intractable epilepsy remains a treatment challenge. Despite impressive advances in epilepsy surgery, there are still some intractable epilepsies that cannot benefit from surgery. Based on theories and research, it is hoped that epilepsy can be treated by means of brain stimulation. Brain pacemaker therapy has had great success in the treatment of neurological disorders such as Parkinson’s disease, primary tremor, and dystonia. Some of the world’s most advanced epilepsy centers are now also using this technology in the treatment of intractable epilepsy. Electrical stimulation offers a new option for patients with intractable epilepsy who are not suitable for surgery, but it is also a very promising treatment for epilepsy. Pacemaker therapy is also one of the distinguishing features of the Beijing Institute of Functional Neurosurgery, which is currently conducting further clinical research on the use of pacemakers for intractable epilepsy in parallel with advanced epilepsy centers around the world, and has also achieved satisfactory results.