Nonpalpable breast lesion (NPBL) refers to a breast lesion that is detected by ultrasound, mammography or other imaging examinations, but cannot be reached by clinical examination, and various breast diseases can be manifested as nonpalpable breast lesions. In the literature, it has been reported that as many as 2% to 4% of women have nonpalpable breast lesions, and about 10% to 30% of them are malignant, of which 75% to 85% are early stage breast cancer (stage 0 to IIa). It is very difficult to perform quadrant resection by traditional open surgery, and the target lesions are often missed, and the missed cases are often diagnosed as locally progressive breast cancer by the time they are diagnosed again. Therefore, the timely diagnosis of non-palpable breast lesions requires not only sensitive diagnostic imaging techniques, but also accurate biopsy of the lesions detected by imaging. Currently, the most widely used biopsy techniques for nonpalpable breast lesions are mammography, ultrasound, and ductoscopy-guided localization and excision. Calcified breast foci are often the specific sign of palpation-negative breast cancer, especially the only form of presentation for some early-stage breast cancers. Mammography is the gold standard for the diagnosis of calcified breast foci, and submammographic localization and excision is the routine treatment recommended by the guidelines. The accuracy of traditional mammography localization is closely related to the experience of the operator and has some subjective limitations. Our hospital uses a three-dimensional mammography positioning system to determine the Z-axis and needle depth based on the data calculated by the positioning system, which avoids errors caused by operator experience and greatly improves the accuracy of puncture positioning of breast calcification foci. In recent years, the resolution of high-frequency ultrasound images has been greatly improved, and ultrasound can detect both the size, shape, and distribution of impalpable breast lesions and their posterior presence of acoustic shadows and fast-flash artifacts, as well as analyze hemodynamics using color Doppler to infer the nature of the lesion. In recent years, with the greatly improved resolution of high-frequency ultrasound images, the application of ultrasound technology to observe calcifications and microcalcifications in superficial organs such as the breast has become a reality, making it possible to localize breast calcification foci by ultrasound-guided puncture. The real-time dynamic ultrasound guidance ensures the accuracy of puncture localization and has the advantages of easy operation and good patient compliance. We have tried to carry out the study of ultrasound-guided puncture localization of breast calcification foci and achieved good results. The patients with nipple discharge, 36% to 52% of which are occupying lesions in the ducts of the breast, including papilloma, papillomatosis, and intraductal carcinoma, mostly require surgical treatment. Ultrasound, mammography and other conventional examinations have no characteristic manifestations and are difficult to locate. The application of mammography has greatly improved the accuracy of the diagnosis of intraductal occupying lesions. For papillary tumors and intraductal carcinomas that are mainly solitary, our department has adopted the new technique of removing the lesions with the guidance of positioning needles under mammography, which has greatly improved the accuracy of surgical resection. For papillomatosis with multiple small breast ducts and end ducts, it is difficult to locate all the lesions because the needle can only be placed in one of the multiple lesions, which may lead to missed excision. The mammogram, ultrasound, and mammogram are used to locate the large breast ducts and the small breast ducts and end ducts. Mammography, ultrasound and ductoscopy guided resection of non-palpable breast lesions with localization needles improves the accuracy of surgical resection of non-palpable breast lesions, reduces tissue damage, and avoids the damage and great psychological stress caused by missed or blindly expanded resection; helps qualitative diagnosis of non-palpable breast lesions, promotes early detection and diagnosis of palpation-negative early breast cancer lesions, and improves the diagnosis of early breast cancer. It improves the diagnosis of early breast cancer, reduces the disability and mortality rate of breast cancer, and improves the quality of life of patients, which has important clinical and social significance.