Before the death of nasopharyngeal carcinoma, there are mostly symptoms of primary lesion, metastatic site symptoms and even obvious systemic symptoms, which may vary from patient to patient, and generally there are mainly the following signs: 1. When the lesion invades into the skull, it produces compression symptoms of cerebral nerve, even cerebral edema and coma; the most serious advanced nasopharyngeal cancer tumor destroys the cervical vertebral artery, causing hemorrhage, and there will be repeated nasal or pharyngeal bleeding in the days before death, and the bleeding is not effectively treated, eventually leading to death by hemorrhage; 2. Metastasis to lung causes respiratory symptoms, such as cough and difficulty in breathing; metastasis to liver causes pain in liver area, ascites, jaundice, etc.; metastasis to brain causes headache, nausea, vomiting and other symptoms of increased intracranial pressure; 3. Energy consumption is very high, and the muscles of the whole body may have atrophied due to bed rest. The signs and symptoms of nasopharyngeal cancer patients before the end of life are not exactly the same, but the overall condition is very poor, and they need nutritional support, psychological care, all kinds of symptomatic treatment, and necessary end-of-life care to improve the quality of survival.