Cholinergic urticaria may cause lip swelling. Cholinergic urticaria is a type of urticaria, a disease in which limited edema occurs in the skin and mucous membranes, with clinical manifestations of angioedema and windswept masses. Some patients may develop on the lips, and then appear swollen lips. In addition, the patient’s skin may also appear round papular eruptions, surrounded by a red halo, often accompanied by intense itching, and in severe cases, even headache, nausea, and tearing and other symptoms. Angioedema caused by cholinergic urticaria may result in swollen lips. In addition, lip swelling may also be caused by other diseases, such as trauma and granulomatous lipitis. Patients go to regular hospitals and cooperate with doctors for relevant examinations.