Papilloma of the larynx is the most common benign tumor of the larynx and can occur at any age, with children under 10 years of age being the most common. Papillomas that occur in children are often multiple, fast-growing, and prone to recurrence. In adults, papillomas of the larynx are mostly solitary and have a tendency to become malignant. Among the various subtypes of HPV, HPV6 and HPV11 are the main pathogenic factors of laryngeal papilloma. Electron microscopy has confirmed the presence of papillomavirus bodies in the cells. It has also been suggested that laryngeal papilloma is associated with chronic irritation of the larynx and endocrine disorders. The laryngeal papilloma is a benign tumor from the epithelial tissue, which consists of a complex squamous epithelium and the underlying connective tissue growing in a papillary pattern towards the surface, without invading the basal tissue. It can be solitary or multiple. Clinical manifestations] 1. Persistent hoarseness Adult patients have a slow development of the disease, and the common symptom is progressive hoarseness, and those with large tumors even lose their voices; pediatric patients often have multiple tumors, which grow faster and are aggravated by progressive hoarseness, and even lose their voices. 2.Respiratory difficulty The tumor is larger which can cause respiratory difficulty. In adult patients, coughing, laryngeal wheezing and dyspnea can occur; in children, the laryngeal cavity is small, fast growing, often multiple, and easy to occur laryngeal obstruction. Recurrence and malignant change Children patients are prone to recurrence, and adult patients may have malignant change. Laryngoscopy shows that the tumor is pale, light red or dark red, with uneven surface and papillary hyperplasia. The base of the tumor is very wide in children, and in adults, a single band tip is more common, which can occur in the vocal cord, ventricular cord and subglottic area. It can also spread to the hypopharynx and trachea. Diagnosis] Diagnosis can be made according to the following: symptoms; laryngoscopy shows grayish or light pink papillary masses in the vocal folds and ventricular folds with good vocal fold activity; biopsy confirms the papilloma. Treatment】 1.Surgery The application of CO2 laser to remove the tumor under support laryngoscopy is the most effective treatment. (1) Childhood laryngeal papilloma In order to avoid tumor dissemination and medical laryngeal stenosis, laryngeal forceps can be used to remove the tumor repeatedly under the laryngoscope. The application of CO2 laser vaporization cautery is most commonly used for clear vision, high accuracy, and low recurrence. (2) Adult laryngeal papilloma can be resected laryngoscopically with support, and laryngeal lysis can be performed to remove it completely if malignancy is suspected. (3) Tracheotomy Tracheotomy is feasible if the patient shows laryngeal obstruction; however, it should be avoided as much as possible to reduce implantation. 2, drugs Mostly used in pediatric patients, the most commonly used is human alpha-interferon, which can reduce recurrence, but can not stop its development, and requires long-term application to be effective.