How long one can live after total gastrectomy surgery is mainly related to the cause of the patient’s disease and cannot be generalized. Total gastrectomy is suitable for the treatment of acute erosive hemorrhagic gastritis and gastric cancer. In the case of acute hemorrhagic gastritis, total gastrectomy can achieve healing after surgery and generally will not affect the normal life expectancy of the patient. If patients with gastric cancer undergo total gastrectomy, how long they can live after surgery depends mainly on the type of pathological diagnosis and stage of the tumor. If it is a highly differentiated adenocarcinoma, which only invades the mucosal layer of the gastric wall without lymph node metastasis or distant organ metastasis, the survival rate of patients can be more than 90% in 5 years after surgery; if it is a low differentiated adenocarcinoma or indolent cell carcinoma, which invades the outer layer of the gastric wall with lymph node metastasis or distant organ metastasis, the survival rate of patients in 5 years after surgery is about 20%. In addition, patients after total gastrectomy need to have regular review and follow medical advice to help prolong survival.