Parkinson’s disease is a common degenerative disease of the nervous system, common in the elderly, with an average age of onset of about 60 years, and less common in young people with PD starting under the age of 40. The prevalence of PD in people over 65 years of age in China is about 1.7%. Most patients with Parkinson’s disease are epidemic cases, and less than 10% have a family history of the disease. The most important pathological change in Parkinson’s disease is the degenerative death of dopaminergic neurons in the midbrain substantia nigra, which causes a significant decrease in striatal DA content and leads to the disease. The exact etiology of this pathological change is still unclear, and genetic factors, environmental factors, ageing, and oxidative stress may all be involved in the degenerative death of PD dopaminergic neurons. Nowadays, more and more people are suffering from Parkinson’s disease, many people do not know how to prevent it, and do not understand the causes of Parkinson’s, so what are the factors that trigger Parkinson’s? 1, the risk factors of the environment is also the cause of the onset of Parkinson’s. Clinical and experimental studies have demonstrated that a substance called 1-methyl-4-phenyl-1. 2, tetrahydropyridine poisoning is associated with the onset of Parkinson’s, and NPTP has been used to make Parkinson’s model for experimental studies. 3, free radical damage and oxidative phosphorylation deficiency is also a cause of Parkinson’s pathogenesis. Current experiments have demonstrated that free radicals are significantly higher in the Parkinson’s patient group than in the control group, and oxidative phosphorylation defects in the mitochondrial complex 1, which are associated with causing damage to mitochondrial DNA as well as other macromolecules. 4, because Parkinson’s patients do not receive treatment on time and reasonably according to medical advice, they add or reduce the dose at will, and even have time to stop treatment. 5, Parkinson’s patients failed to get timely diagnosis and treatment due to their own or consultation reasons and delayed Parkinson’s disease, losing the best time for treatment. Although understanding the causes of Parkinson’s can be effectively prevented, there are still some people who will unfortunately suffer from the disease, so we should also pay some attention to the treatment of Parkinson’s. A good prevention of Parkinson’s from the source of the disease in life can effectively reduce the incidence of Parkinson’s and return everyone to a healthy living environment.