Parkinson’s disease primarily affects a person’s ability to move, which we call motor symptoms. These symptoms are the main basis for our diagnosis of Parkinson’s disease. Typical motor symptoms include four aspects, there are two aspects of the symptoms to consider the possibility of Parkinson’s disease. 1, slow movement: manifested as slow movements. Walking is not fast enough to keep up with peers. Due to the slow facial movements, facial expression is dull, and the smile is not natural when you are happy. Some patients feel that they can’t lift their feet when walking, and they feel weak. The upper limb on the affected side does not swing when walking, as if the arm is tied up. Patients are often less active, sitting at home and not moving. Slow movement can affect all aspects of daily life, writing becomes smaller and smaller, dressing becomes difficult, often needing help from others, and turning over in bed can be difficult. Chen Haibo, Department of Neurology, Beijing Hospital 2. Tremor: The tremor of Parkinson’s disease is called resting tremor, i.e., the tremor occurs when the limbs are relaxed and quiet, and the tremor decreases or disappears when the limbs are active. About 50% of Parkinson’s disease patients’ first symptom is tremor, which is one of the main symptoms of Parkinson’s disease, and the tremor is characterized by rhythmic tremor of large amplitude. The tremor starts in one hand and gradually spreads to other limbs. The tremor is aggravated in anger and reduced when the mood is stable, and it can be completely terminated during sleep. The tremor can be temporarily suppressed by strong willful effort, but it is short-lived and tends to worsen afterward. Resting tremor is sensitive to weather changes and is also a sign of good or bad general condition. In elderly Parkinson’s disease patients with infection or pneumonia, the tremor may disappear completely. It will reappear with the recovery of the general condition. 3.Muscle Tonicity: It refers to the increase of muscle tension. The patient often feels stiffness in the muscles, and the muscles can not be relaxed as if they are tied up. There is obvious resistance when pulling the patient’s limbs, which seems very stiff. The increased muscle tone is always consistent, and the feeling of uniform resistance, similar to the sensation of bending a lead pipe, is called lead pipe-like ankylosis. Those with tremor may feel intermittent pauses in the uniformly increased resistance, like the rotation of a gear, so it is called “cogwheel-like ankylosis”. In the more severe cases, the head often hangs in mid-air for several minutes when the patient is lying down, as if there is a pillow under the head, and when the patient lifts the limb and then relaxes it, the patient often maintains the limb in the air for several minutes and finds it difficult to put it down. In elderly patients, the above mentioned muscle ankylosis can cause pain in the joints, which is sometimes misdiagnosed as arthropathy for a long time. Sometimes, hip joint pain can occur when standing and walking, which is due to the increase in muscle tone, so that the blood supply of nutritive blood vessels in the joints is blocked and the muscle strength is reduced, and the joints are compressed by the weight of the patient. Some patients feel weak due to increased muscle tone in the lower limbs. When the symptoms are limited to one side of the limbs, patients often complain of weakness of one side of the limbs and are often misdiagnosed as cerebrovascular disease. 4. Postural and balance disorders: among all the symptoms of Parkinson’s disease, postural and balance disorders may be the least specific manifestation, but the symptoms have the heaviest impact on life. Postural balance disorders are most common in patients with middle to late stage Parkinson’s disease and often lead to femur fracture due to the ease of falling. Due to muscle tonus, the patient has a specific posture, with the head tilted forward, the trunk flexed, the elbow joints of the upper limbs flexed, the wrist joints straightened, and the hands placed in front, the hip and knee joints of the lower limbs slightly flexed, and due to the imbalance of the increased muscle tone on both sides of the trunk, the patient may have a sideways curvature of the trunk. Gait disorder is also a prominent manifestation of Parkinson’s disease. When walking, the gait is shuffling, it is difficult to start, and after taking a step, the patient rushes forward with a very small step, walking faster and faster, and cannot stop or turn instantly, which is called panic gait. When turning, it is necessary to take consecutive small steps to turn the torso and head together. Because of the balance disorder, the patient tends to fall forward when walking. Patients with postural balance disorders associated with trunk tonus and hyperkinesis often fall back in their chairs when trying to sit down. The above symptoms should be seen by a doctor as soon as possible for early diagnosis and treatment.