Limb tremor, mask face, slow action, and even anxiety, cognitive impairment …… In recent years, Parkinson’s disease shows a trend of rejuvenation. China has more than 2 million Parkinson’s disease patients, of which “adolescent Parkinson’s disease” patients accounted for about 10% of the total number. Parkinson’s disease is the third largest killer of elderly health Parkinson’s disease is a common chronic degenerative movement disorder of the central nervous system in middle-aged and elderly people, and has become the third largest killer of elderly people’s health, second only to tumors, cardiovascular and cerebrovascular disease, which is a serious threat to the health of the elderly population. With the arrival of the aging society, Parkinson’s disease patients are increasing year by year, causing more and more patients to pay attention. But Parkinson’s is not just a disease of the elderly, more and more clinical practice shows that Parkinson’s disease has a trend of rejuvenation. Early symptoms of Parkinson’s disease are similar to those of many other diseases, making it easy to misdiagnose. Family members or patients themselves should not jump to conclusions based on symptoms alone. Especially in the first one or two years before the onset of the patient, it is not easy to distinguish. We would like to remind you that tremor, rigidity, bradykinesia, and abnormal posture or gait are the four main symptoms of Parkinson’s disease, in addition to some non-motor symptoms such as sleep disorders, mental abnormalities, sensory disorders, and autonomic dysfunction. In daily life and work, if you find that you or your family members have some slow or sluggish movements, or even the phenomenon of shuffling steps, you should go to the hospital as soon as possible for further diagnosis. Parkinson’s disease has different treatments at different times, and patients should not expect to see an outpatient clinic once and be set on the medication they will take for the rest of their lives. Doctors will formulate different treatment plans according to the different periods of the disease, and patients should follow up at the outpatient clinic at least once a quarter. If there is no change in the condition of the original medication, if there are new changes should be adjusted, once the drug-induced dyskinesia complications and drug efficacy decline, the drug adjustment after no significant improvement in patients should be considered to take surgical treatment. After the onset of Parkinson’s disease patients, there will be a better drug treatment time, people call it “honeymoon period”. It refers to the early or middle stage of Parkinson’s disease in the first few years of taking fewer types and smaller doses of drugs, can be more satisfactory and sustained results, usually patients in the honeymoon period of the quality of life is higher, normal work, life is not affected. After 3-5 years, more than half of the patients develop insurmountable movement disorder complications such as anisocoria and fluctuating symptoms. Many patients, after the honeymoon period, will still hold the mentality of trying again with a different drug, expecting that they can still create another honeymoon with the new drug, until they have to choose surgical treatment after failing to try every single drug. This practice not only affects one’s life, but also delays the best time for surgical treatment. Therefore once the drug honeymoon period is gone, the need for surgical treatment should be considered. Which Parkinson’s disease patients need surgery? Deep Brain Stimulation (DBS, commonly known as brain pacemaker) surgery for Parkinson’s disease requires a rigorous pre-operative evaluation. Patients with primary Parkinson’s disease, who have had an effect on levodopa-based medication, whose symptoms can no longer be controlled after a full course of medication or who develop comorbidities of dyskinesia that do not improve with adjustments in medication, and who do not have severe cognitive and psychiatric deficits, who are able to cooperate with the surgery, and who are able to have a regular follow-up after the surgery are able to tolerate the DBS procedure and have an opportunity for surgical treatment. DBS surgery is a minimally invasive procedure in which electrodes are implanted into the corresponding control nuclei of the brain under the guidance of a precise localization system, and a stimulator is implanted under the skin of the chest. The electrical impulses emitted by the stimulator block the generation of abnormal signals and help the patient to rebuild the neural conduction pathways in order to control the symptoms of Parkinson’s Disease. The key to the procedure is to place the electrodes in the most appropriate position in the nucleus pulposus, which is the size of a pea, with the support of a precise localization system. Therefore, pacemaker implantation is a highly accurate and minimally invasive surgery. Surgical skills cannot be mastered in a single day. This is where the selection of the surgical specialist is particularly important. It can be seen that the treatment of Parkinson’s disease is a comprehensive treatment process, neurology, neurosurgery, neuromodulation, neuropsychology is indispensable, need to work closely with the team, DBS surgery to achieve good surgical results in the choice of the right timing of the operation, the right surgical hospital, the right surgical experts is the key to reduce the risk of surgery.