The treatment of cholera: first of all, close isolation, according to the gastrointestinal isolation measures of class A infectious diseases, until the patient’s symptoms disappear, fecal culture of Vibrio cholerae for three consecutive times are negative before the isolation can be released. Next is rehydration, this is the main treatment measures, mild patients only need oral rehydration, mostly choose oral rehydration salt. In case of moderate or severe cases, intravenous rehydration is required, which can be supplemented with Ringer’s solution, sodium chloride, glucose, etc. Attention should also be paid to acid correction and electrolyte replenishment, but the patient’s vomiting and diarrhea will decrease in number and then be switched to oral rehydration. Antibacterial treatment can be based on the results of drug sensitivity test to choose sensitive antibiotics, if no drug sensitivity test, you can also choose levoxyl, doxycycline or sulfonamides, these drugs can make the patient’s fecal Vibrio cholerae reduce, so as to reduce the patient’s symptoms and shorten the course of the disease. The last is symptomatic treatment, mainly to correct acidosis, hypokalemia, shock and heart failure, etc.