Cholera is an acute intestinal infection caused by Vibrio cholerae. The main clinical manifestations of severe cholera patients are severe diarrhea, vomiting, dehydration, muscle cramps, circulatory failure, accompanied by severe electrolyte disorders and metabolic acidosis. If resuscitation is not timely, death can occur within a few hours or tens of hours. China’s Infectious Disease Control Law stipulates that cholera is a Class A infectious disease, and the strict isolation measures for Class A infectious diseases are used. Treatment on the rapid establishment of two or more intravenous channels, timely replenishment of adequate amounts of water and electrolytes, correction of dehydration, acidosis, to prevent acute renal failure and hypokalemia, the choice of effective antibiotics. For patients with severe disease, strict gastrointestinal isolation is implemented until six days after the disappearance of symptoms, stool culture once a day, two consecutive negative Vibrio cholerae will be released from isolation. In terms of health education, the prevention of cholera must implement the “prevention-oriented” policy, adhere to the principle of “treating both the symptoms and the root causes,” the targeted grasp of “three tubes and one extermination” comprehensive measures. Measures. Every year before the epidemic, the community to do a good job of health publicity and education, improve environmental hygiene, actively kill maggots and mosquitoes, do not defecate anywhere, strictly prohibit the use of new manure fertilizer, ensure water safety, advise not to drink raw water, do not eat raw, cold, spoiled food, especially aquatic products, seafood, to cooked, cooked thoroughly before consumption. Wash your hands after defecating, separate raw and cooked cooking utensils, and develop good living habits.