Hydrochlorothiazide is generally not recommended for diabetics. Hydrochlorothiazide is mainly used for edematous diseases, such as congestive heart failure, cirrhosis, ascites, nephrotic syndrome, hypertension, central or renal diabetes insipidus. It is not suitable for diabetic patients, can reduce glucose tolerance, make blood glucose increase, is not conducive to the control of diabetic blood glucose. The side effect of hydrochlorothiazide tablets is that it can affect the metabolism of blood glucose, blood lipids and blood uric acid, which can increase blood glucose, so diabetic patients are better not to take this kind of drug. Contraindications of hydrochlorothiazide is not clear, but may appear water electrolyte disorders, hyperglycemia, hyperuricemia, allergy, blood leukopenia or deficiency, thrombocytopenic purpura and other adverse reactions, it is recommended to stop the drug in time to see a doctor. In addition, it is recommended that diabetic patients follow the doctor’s instructions for treatment, and those who need to use hydrochlorothiazide should use it under the guidance of a doctor, and should not use it privately.