When a woman has no follicles, it may be caused by polycystic ovary syndrome, premature ovarian failure, hyperprolactinemia, which requires timely examination of the ovaries in a regular medical institution, and then choose a suitable treatment for the cause. 1. polycystic ovary syndrome: it develops mostly in adolescence and may be related to genetic and environmental factors. The menstrual cycle can be regulated by taking short-acting oral contraceptives and progestin under the guidance of a doctor. Most patients have obesity and need lifestyle interventions such as diet control and exercise. 2. Premature ovarian failure: chromosomal abnormalities and autoimmune diseases are the main causes of premature ovarian failure, which can manifest as secondary amenorrhea, infertility and the absence of follicles. There is no exact method to restore ovarian function. For adolescent females, ovulation-promoting drugs can be applied to promote follicle development. For fertile females, estrogen supplementation therapy can be applied. 3. Hyperprolactinemia: abnormally elevated serum prolactin, causing menstrual disorders and infertility, breast overflow, amenorrhea, and changes in sexual function.