The full name of very early onset inflammatory bowel disease is very early onset inflammatory bowel disease, and treatment includes medications (e.g., methylprednisolone, salazosulfapyridine), surgery, and transplantation. Very early-onset inflammatory bowel disease is related to immunity, genetics, infection, diet and other factors, and the treatment is often comprehensive. 1. Drug treatment: such as methylprednisolone, dexamethasone and other hormones; salicylate preparations such as salazosulfapyridine, mesalazine and other aminosalicylic acid preparations; cyclophosphamide, cyclosporine and other immunosuppressive agents. 2. Surgery: If the response to drug treatment is poor, and the inflammation of the intestine is severe and lasts for a long time, partial or subtotal colectomy can be considered to control the development of the disease. 3. Transplantation: Hematopoietic stem cell transplantation can be used for very early-onset inflammatory bowel disease caused by IL10/IL10R mutations, while other mutations are not as effective. For the treatment of very early-onset inflammatory bowel disease, it is recommended to consult a doctor in a timely manner and follow the advice and guidance of a medical professional.