Vagus Nerve Stimulation (VNS) was first recognized in the 1930s as a way to induce changes in electrical activity in the brain, and was first proposed by Zabara in 1985 for the treatment of epilepsy. In 1988, Cyberonics successfully developed a vagus nerve stimulation device for clinical application. The VNS procedure is performed by implanting a stimulator under the left clavicle, with the stimulator electrodes fixed to the cervical vagus nerve, and the chest wall stimulator continuously emitting electric current to cause changes in brain electrical activity and neurotransmitters for the treatment of epilepsy. To date, more than 80,000 patients have been treated with vagus nerve stimulation in over 75 countries worldwide. 2000 saw the introduction of this technique into China, and more than 400 surgeries have been performed with good results. VNS is mainly suitable for patients with refractory epilepsy that cannot be controlled by drugs, but not suitable for craniotomy or unwilling to open the cranium, and whose clinical manifestations are generalized or partial seizures. The procedure has the advantages of being safe, minimally invasive, modifiable, and with long-term results. Effectiveness of VNS vagus nerve stimulation therapy Seizures can be significantly reduced or completely controlled in patients after VNS treatment. According to foreign multicenter reports, VNS can reduce seizures in patients by about 50%, and about 10% of them can be completely controlled. Not only that, the treatment has shown significant improvements in improving patients’ quality of life, such as alertness, recovery time after seizures, reduction of cascade seizures, language skills, manual skills, thinking skills, mood, memory, and independence. Long-term effectiveness of VNS vagus nerve stimulation VNS differs from other therapies also in the long-term nature of the treatment. The parameters of the pulsed current, depending on the patient’s different episodes, can be regulated at any time by means of an external programmable controller in order to find the most suitable stimulation parameters for the patient and to achieve the optimal state. The external magnets provided also allow the patient himself, depending on the specific situation, to simply change the form of stimulation to block the impending seizures, contributing to further stabilization of the treatment.